Art Pappas

Valentis lead drug candidate, Deltavasc, may treat peripheral arterial and ischemic heart disease with a gene that spurs new blood vessels to form (a process known as angiogenesis). In early stages of development are DNA vaccines for HIV, hepatitis C, and other viral infections. Another drug candidate, eNOS, could prevent tissue rejection in transplant recipients. The company licenses its technology -- include the GeneSwitch platform, which can turn off or on gene therapies -- to other drugmakers. These licensees include Genzyme, Pfizer, and GlaxoSmithKline.

AtheroGenics is a pharmaceutical company focused on the discovery, development and commercialization of novel drugs for the treatment of chronic inflammatory diseases, such as atherosclerosis, asthma and arthritis.

NuVasive, Inc. engages in the development, manufacture, sale, and provision of procedural solutions for spine surgery. It offers a comprehensive portfolio of procedurally integrated spine surgery solutions, including surgical access instruments, spinal implants, fixation systems, biologics, and enabling technologies, as well as systems and services for intraoperative neuromonitoring. The company was founded by Alexis V. Lukianov on July 21, 1997 and is headquartered in San Diego, CA.

Bioverativ Therapeutics, Inc. develops pharmaceutical products. It develops medicines for chronic diseases such as hemophilia, anemia, multiple sclerosis, and autoimmune disorders. The company is headquartered in Cambridge, MA.

TYRX, Inc. designs and manufactures medical-pharmaceutical combination devices. The firm commercializes implantable combination drug and device products focused on infection control including the AIGISRx Antibacterial Envelope, designed to reduce surgical site infections associated with cardiac implantable electronic devices (CIEDs). Its AIGISRx products contain the antimicrobial agents, rifampin and minocycline, which have been shown to reduce infection by pathogens responsible for the majority of CIED infections, including superbugs such as methicillin-resistant S. aureus (MRSA). The company was founded in 1998 by Satish Pulapura and Arikha Moses and is headquartered in Monmouth Junction, NJ.

CardioDx, Inc. operates as a cardiovascular genomic diagnostics firm. It develops proprietary tests that improve treatment decisions and patient outcomes on coronary artery disease, cardiac arrhythmia, and heart failure. The company was founded by David L. Levison and Christopher R. Burrow in 2004 and is headquartered in Redwood, CA.

CeNeRx BioPharma, Inc. was manufactured pharmaceutical products. The company was founded in October 2005 by James Free, Barry Brand, and Mark J. Baric and was headquartered in Cary, NC.

CoLucid Pharmaceuticals, Inc. engaged in the development of therapeutics for neurological disorders. Its products included Lasmiditan, a neurally acting anti-migraine agent that is designed to delivered efficacy in migraine without the vasoconstrictor activity associated with previous generations of migraine therapies and a Conjugated Stigmines platform that has generated a series of preclinical candidates for the chronic pain, Alzheimer's disease and psychiatric disorders. The company was founded by James F. White and Arthur M. Pappas in 2005 and was headquartered in Cambridge, MA.

LEAD Therapeutics, Inc. develops therapeutic drugs. The company was founded Charles Hsu, Leonard E. Post, Peter L. Myers and Sofie Qiao in May 2006 and is headquartered in San Bruno, CA.

Afferent Pharmaceuticals, Inc. develops selective drugs for the treatment of debilitating neurogenic disorders. It offers programs for respiratory, cardiovascular, chronic pain, biology, and clinical trials. The firm offers drugs for osteoarthritis pain, treatment-refractory chronic cough, and interstitial cystitis or bladder pain syndrome. The company was founded by Anthony P. Ford in December 2009 and is headquartered in San Mateo, CA.

Pappas Capital LLC (Pappas Ventures) is a venture capital firm founded in 1994 by Art M. Pappas. The firm is headquartered in Durham, North Carolina.

Selventa, Inc. develops new approaches for the understanding and treatment of diseases. It focuses on elucidating the complexity of biology for the development of safe and effective therapeutics and molecular diagnostics. The company was founded in 2002 by Keith O. Elliston and Noubar B. Afeyan and is headquartered in Cambridge, MA.

The Wistar Institute provides biomedical research services. It researches on diseases such as cancer, cardiovascular, autoimmune disorders and infectious diseases and develops vaccine. The company was founded in 1892 and is headquartered in Philadelphia, PA

The North Carolina Biotechnology Center provides research and education grants. Its services include financing, technology assessment, business planning, and marketing strategies implementation. The company was founded in 1984 and is headquartered in Research Triangle Park, NC.

National Venture Capital Association provides business association services. It facilitates networking opportunities and provides research data to its members. The company is headquartered in Washington, DC.

The BioExec Institute, Inc. is a network of executives in the life sciences industry. The private company is based in Cambridge, MA. The company was founded in 2004 by Hoda Jeanne Abou-Jamra. Hoda Jeanne Abou-Jamra has been the CEO since 2004.

Real Endpoints LLC provides information and analytics services. It offers information platform to reveal insights about the changing world of product reimbursement. The firm operates its business through Reimbursement Intelligence and RxScorecard. The company was founded by Roger Longman in 2010 and is headquartered in Westport, CT.

Pappas Capital Management is an investment advisory company. The private company is based in San Francisco, CA. The company provides investment advice to its clients. The company was founded by Art M. Pappas.

Part of Abbott Laboratories, Abbott Laboratories International LLC is a private company that wholesales hospital equipment. The company is based in Abbott Park, IL.

Chiesi Ventures, Inc.(Chiesi Ventures) is an venture capital firm founded in 2014. The firm is headquartered in Boston, Massachusetts.

OrphoMed, Inc. develops and manufactures pharmaceutical products. The company was founded Pankaj Jay Pasricha and Frank Steinberg and is headquartered in Mill Valley, CA.

AgTech Accelerator Corp. focuses on discovering and developing agricultural technology companies. It offers finance to agricultural firms. The company was founded in 2003 and is headquartered in Durham, NC.

A.M. Pappas Life Science Ventures V LP operates as a venture capital fund. The company is headquartered in Durham, NC.

Duke Cancer Institute is an organization that unites the academic and clinical communities of Duke University and the Duke University Health System. The non-profit company is based in Durham, NC and has subsidiaries in the United States. The company's main focus is to provide access to technologies, services, and scientific consultation through its Shared Resources.

Allievex Corp. operates as a biotechnology company. It develops therapies for the treatment of rare pediatric neurodegenerative diseases. The company was founded by Thomas P. Mathers and Eric H. Zanelli and is headquartered in Marblehead, MA.

Sorriso Pharmaceuticals, Inc. is an American biotechnology company that focuses on developing disease-modifying antibodies to treat inflammatory diseases. Sorriso Pharmaceuticals was founded by Ciara Kennedy, who has been the CEO since its incorporation.