Andrew Perlman

Sirtris Pharmaceuticals, Inc., a GSK company, is developing small molecule drugs that target the sirtuins, a family of seven enzymes associated with diseases of aging. Modulation of these enzymes offers the promise of drug discovery in multiple therapeutic areas. Sirtris was one of the pharmaceutical companies focused on the sirtuin platform and remains the innovative drug discovery. Preclinical research indicates that the sirtuins play important roles in pathways for multiple diseases of aging, including Type 2 Diabetes, as well as neurodegenerative, cardiovascular and inflammatory diseases. Sirtris researchers are working to translate this research into a potential new class of pharmaceuticals to treat diseases of aging, offering the ability for people to live longer, healthier lives. Sirtris has focused on developing many novel small molecule activators of SIRT1, the most studied member of the sirtuin family. These new chemical entities or NCEs are novel compounds that are chemically unrelated to resveratrol, a naturally occurring compound that was used as an early proof-of-concept for SIRT1 activation. Besides being structurally differentiated from resveratrol, the NCEs are more specific for the target SIRT1 and have improved drug-like properties. The company has completed several early stage translational clinical studies with the first generation NCEs and has several active clinical trials under way. Sirtris operates as an independent Discovery Performance Unit (DPU) within GSK and is located in Technology Square, Cambridge, Mass. Sirtris' culture mixes scientific curiosity with a dynamic, fast-paced environment, resembling its biotech roots while harnessing all of GSK's broad discovery, development, and commercialization capabilities. The company was founded in 2004 and is headquartered in Cambridge, MA.

GreatPoint Energy, Inc. develops, owns, and operates blue gas production facilities. It offers bluegas technology, a catalytic hydromethanation process by which coal, petcoke, and biomass are converted through a combination of catalytic reactions in the presence of water into a methane-rich gas stream. The company was founded by Andrew Perlman in 2004 and is headquartered in Cambridge, MA.

Coskata, Inc. engages in gas fermentation. The company was founded in July 2006 and is headquartered in Warrenville, IL.

Zafgen, Inc. is a biopharmaceutical company, which engages in the development of novel therapies for patients affected by complex metabolic diseases. It focuses on the study of MetAP2 inhibitors in both common and rare metabolic disorders. The firm also advancing programs for type 2 diabetes, Prader-Willi syndrome, and liver diseases. The company was founded on November 22, 2005 and is headquartered in Boston, MA.

AltaRock Energy, Inc. develops and commercializes geothermal technology. It develops and commercializes geothermal technology to produce clean and renewable power. The company was founded by Robert Banack, Aaron H. Mandell and Susan Petty in 2007 and is headquartered in Seattle, WA.

AMP Americas LLC operates as an integrated transport company. The company was founded by Nathan Laurellis and Steve Josephs in 2011 and is headquartered in Chicago, IL.

Part of Liberty Global Ltd., Cignal Global Communications, Inc. is an internet service provider. The company is based in Cambridge, MA. The company was founded by Neal C. Isaacson, Andrew Perlman. Cignal Global Communications was acquired by United Pan-Europe Communications NV on April 01, 2000.

Part of Advanced Micro Devices, Inc., Coatue Corp. is one of the largest dedicated technology funds in the world. Coatue has offices in different locations and is based in Woburn, MA. The company's dedicated team of engineers and data scientists works closely with investment professionals to add value to founders and executive teams in their portfolio. Some of their private investments include airtable, ant financial, anaplan, bytedance, chime, databricks, doordash, instacart, meituan, snap, snowflake, and spotify. The company, founded by Andrew Perlman, Aaron H. Mandell, and Avi Y. Goldberg, manages approximately $17 billion in assets on behalf of individuals, endowments, foundations, and other institutional investors. Coatue was acquired by Advanced Micro Devices, Inc. from ITU Ventures LLC on August 05, 2003.

Greatpoint Investment Management, LLC (GreatPoint Ventures) is a venture capital firm founded in 2004 by Andrew Perlman, Avi Y. Goldberg and Aaron H. Mandell. The firm is headquartered in San Francisco, California.